Set up content types, taxonomies and blocks. Classify and group your content using taxonomies and views. Views helps to group the content in a different sections such as latest news, featured articles, services and all necessary website widgets.
Plan your strategy to use Drupal at the best of its capability and performance. As Drupal is written in PHP it requires that a module is loaded when needed, therefore it is highly recommended to install a module only if it is really necessary. Decide in advance which modules to use in your project.
Integrate Drupal with other systems using the web services API module. They can be used for reading feeds, exchange data between complex systems which generally produce Jason or XML files.